Description

Anadin Extra Soluble Tablet 545mg-12s
What your medicine is and what it is used for
Each tablet contains: 300 mg of Aspirin, 200 mg of Paracetamol and 45 mg of Caffeine.
Aspirin and paracetamol work by relieving pain and reducing high temperature and fever. Aspirin belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and has anti-inflammatory properties. In addition, your medicine contains caffeine, which increases the pain-relieving effect of the product.

Your medicine is for effective relief from: mild to moderate pain including headache, migraine, neuralgia, toothache, sore
throat, period pains, symptomatic relief of sprains, strains, rheumatic pain, sciatica, lower back pain (lumbago), fibrositis, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds.

 Before you take your medicine
Please read the following information. There is a possible association between aspirin and Reye’s syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver and can be fatal. For this reason aspirin
should not be given to children aged under 16 years, unless on the advice of a doctor.
Do not take if you:
• are allergic to aspirin, paracetamol, caffeine, or any of the other ingredients listed in this leaflet
• have or have ever had a stomach ulcer, perforation or bleeding
• suffer from haemophilia (your blood does not clot well) or from gout
• are breast feeding
• suffer from asthma caused by aspirin or other NSAIDs
• are in your 3rd trimester of pregnancy.
Take special care and talk to a pharmacist or your doctor before taking this medicine if you:
• suffer from asthma, allergic disease, have a history of gout, kidney or liver disease (including alcoholic liver disease), dehydration
or phenylketonuria (otherwise known as PKU, a condition where there is an excess of phenylalanine in
your blood) or G-6-PD deficiency (an hereditary condition leading to low red blood cell counts).
• are pregnant.
• Excessive intake of caffeine (e.g., coffee, tea and some canned drinks) should be avoided.
• Consumption of alcohol should be avoided.
Taking other medicines
Anadin Extra Soluble should not be used together with other non-steroidal anti-inflammatory drugs (NSAIDs).
Please inform your doctor or pharmacist if you are taking:
• flucloxacillin (antibiotics), due to a serious risk of blood and fluid abnormality (high anion gap metabolic acidosis) that
must have urgent treatment and which may occur particularly in case of severe renal impairment, sepsis (when
bacteria and their toxins circulate in the blood leading to organ damage), malnutrition, chronic alcoholism, and if the
maximum daily doses of paracetamol are used.

This medicine should also be used with caution when taking the following:
• Other NSAIDS and corticosteroids: Do not use in combination with other NSAIDs as these may increase the risk of adverse effects.
• medicines to treat blood clots (thrombolytics and anticoagulants) as there is an increased risk of bleeding.
• medicines used to treat gout (probenecid, sulfinpyrazone) as there may be an increase of aspirin in the patients plasma levels.
• medicines used to treat high blood pressure due to risk of kidney failure.
• anti-sickness medicines (metoclopramide) as it may increase the rate of absorption of aspirin.
• medicines used to treate seizures (phenytoin) as aspirin increases the serum level of phenytoin.
• medicines used to treat epilepsy and bipolar disorder (valproate) as aspirin inhibits the metabolism of valproate.
• medicines used to treat rheumatoid arthritis (methotrexate). Use of methotrexate with aspirin, renal function should be measured.
• medicines used to treat diabetes (sulphonylureas) as aspirin can increase the hypoglycaemic effect.
• medicines used to treat indigestion (antacids) as use with this medicine may increase the excretion of aspirin.
• antidepressants (SSRIs) as there is a risk of bleeding in the abdomen.
• medicines to treat high cholesterol (cholestyramine). Paracetamol absorption is reduced.
• medicines used to treat nausea and vomiting (metoclopramide and domperidone) as paracetamol absorption is increased.
• medicines used to treat blood clots (warfarin) as there is an increased risk of bleeding.
Consumption of alcohol and excessive caffeine intake should be avoided