Description

Anadin Extra Caplets

What your medicine is and what it is used for:
Each tablet contains: 300 mg of Aspirin, 200 mg of Paracetamol and 45 mg of Caffeine.
Aspirin and paracetamol work by relieving pain and reducing high temperature and fever. Aspirin
belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and has
anti-inflammatory properties. In addition, your medicine contains caffeine, which increases the pain-relieving effect of the product.

Your medicine is for effective relief from: mild to moderate pain including headache, migraine, sharp
nerve pain (neuralgia), toothache, sore throat, period pains, symptomatic relief of sprains, strains,
rheumatic pain, nerve pain of the lower back or legs (sciatica), lower back pain (lumbago), chronic
muscle pain, sometimes with tiredness and skin sensitivity (fibrositis), muscular aches and pains, joint
swelling and stiffness, influenza, feverishness and feverish colds.

Before you take your medicine
Please read the following information. There is a possible association between aspirin and Reye’s
syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and
liver and can be fatal. For this reason aspirin should not be given to children aged under 16 years,
unless on the advice of a doctor.
Do not take if you:
• are allergic to aspirin, paracetamol, caffeine, or any of the other ingredients listed in this leaflet
• have or have ever had a stomach ulcer, perforation or bleeding
• suffer from haemophilia (your blood does not clot well) or from gout
• are breast-feeding.
• suffer from asthma caused by aspirin or other NSAIDs
• are in your 3rd trimester of pregnancy.
Take special care and talk to a pharmacist or your doctor before taking this medicine if you:
• suffer from asthma, allergic disease, dehydration, have a history of gout, liver or kidney disease
(including alcoholic liver disease) or G-6-PD deficiency (an hereditary condition leading to low red
blood cell counts).
• are pregnant.
• Excessive intake of caffeine (e.g., coffee, tea and some canned drinks) should be avoided.
• Consumption of alcohol should be avoided.

Taking other medicines
Anadin Extra should not be used together with other non-steroidal anti-inflammatory drugs (NSAIDs).
Please inform your doctor or pharmacist if you are taking:
• flucloxacillin (antibiotics), due to a serious risk of blood and fluid abnormality (high anion gap
metabolic acidosis) that must have urgent treatment and which may occur particularly in case of
severe renal impairment, sepsis (when bacteria and their toxins circulate in the blood leading to
organ damage), malnutrition, chronic alcoholism, and if the maximum daily doses of paracetamol are used.
This medicine should also be used with caution when taking the following:
• Other NSAIDS and corticosteroids: Do not use in combination with other NSAIDs as these may
increase the risk of adverse effects.
• medicines to treat blood clots (thrombolytics and anticoagulants) as there is an increased risk of bleeding.
• medicines used to treat gout (probenecid, sulfinpyrazone) as there may be an increase of aspirin in
the patients plasma levels.
• medicines used to treat high blood pressure due to risk of kidney failure.
• anti-sickness medicines (metoclopramide) as it may increase the rate of absorption of aspirin.
• medicines used to treate seizures (phenytoin) as aspirin increases the serum level of phenytoin.
• medicines used to treat epilepsy and bipolar disorder (valproate) as aspirin inhibits the metabolism
of valproate.
• medicines used to treat rheumatoid arthritis (methotrexate). Use of methotrexate with aspirin,
renal function should be measured.
• medicines used to treat diabetes (sulphonylureas) as aspirin can increase the hypoglycaemic effect.
• medicines used to treat indigestion (antacids) as use with this medicine may increase the excretion of aspirin.
• antidepressants (SSRIs) as there is a risk of bleeding in the abdomen.